Endocrine Abstracts

The endogenous thyroid hormone metabolite 3,5-diiodothyronine (3,5-T2) has attracted attention as a metabolically active substance modulating metabolism via classical thyroid hormone (TH) receptor-dependent and rapid plasma membrane, cytosolic and mitochondrial signaling pathways. Accordingly, 3,5-T2 has been proposed as a potential hypolipidaemic agent without inducing thyromimetic effects and is frequently used as illicit weight-reducing agent. The objective of the present s...

Recent findings revealed 3,5-diiodo-L-thyronine (3,5-T2) as a metabolically active iodothyronine affecting hepatic energy and lipid metabolism. Therefore, 3,5-T2 has been proposed as a potential hypolipidemic agent for treatment of obesity and its hepatic aftermath. So far only limited data exists relating to the effects of 3,5-T2 on metabolism in euthyroid mammals maintained on high-fat diet from the day of weaning onwards. Therefore, we performed a study in wh...

The melanocortin 4 receptor (MC4R) represents the major hypothalamic G-protein coupled receptor (GPCR) controlling feeding behavior and therefore body weight regulation. MC4R is highly expressed in the paraventricular nucleus (PVN) where hormonal and neuroendocrine signals from periphery and arcuate nucleus (ARC) are allocated. MC4R knockout in mice or natural occurring loss-of function variants result in hyperphagia and early-onset obesity. MC4R mutations represent the most f...